منابع مشابه
Natural Products Synthesis
Rhizopodin (1, Scheme 1) is an architecturally unique polyketide macrolide that was originally isolated from the myxobacterium Myxococcus stipitatus by the groups of Hçfle and Reichenbach. It shows potent antifungal and antiproliferative cytotoxicity against a range of tumor cell lines with IC50 values in the low nanomolar range. [1] On a molecular level, 1 disrupts the cytoskeleton of actin by...
متن کاملGenetically engineered synthesis of natural products.
The feasibility of multi-step, one-flask total synthesis of natural products is demonstrated by cloning and overexpression of the corresponding biosynthetic enzymes from plant and microbial sources. As many as eight or nine enzymes can be recombined in vitro to reach an advanced intermediate in the vitamin B12 pathway.
متن کاملNatural products in synthesis and biosynthesis II
As a continuation of the first two Thematic Series in the Beilstein Journal of Organic Chemistry on natural products in 2011 and 2013 [1,2], it is my pleasure to present the third issue on this topic. Natural products continue to be an inspiring field of research and an important source of potent biologically active compounds. This was recently highlighted by the fact that last year’s Nobel Pri...
متن کاملNatural products in synthesis and biosynthesis
This article is part of the Thematic Series "Natural products in synthesis and biosynthesis". This is the second Thematic Series in the Beilstein Journal of Organic Chemistry focused on natural products. While the first Thematic Series summarized recent research work on the biosynthesis and function of natural products [1,2], the present Thematic Series deals with synthetic and biosynthetic asp...
متن کاملSynthesis of pyran and pyranone natural products.
An overview of the synthesis of the fungal metabolites (+)-dermolactone, (-)- semixanthomegnin, (+)- and (-)-mellein, (-)-ochratoxin alpha, (-)-(1R,3S)-thysanone, the enantiopure ventiloquinones L, E and G, and 8-desmethyleleutherin from a common chiral intermediate, is presented. Further methodology leading potentially toward extended quinones such as (3S,3'S)-xylindein is also outlined.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pure and Applied Chemistry
سال: 1989
ISSN: 1365-3075,0033-4545
DOI: 10.1351/pac198961030313